物质信息
ID:385515
4-Fluoro-α-(2-methyl-1-oxopropyl)-γ-oxo-N,β-diphenyl-benzenebutanamide
名称和标识
IUPAC标准名
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide
IUPAC传统名
2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide
别名
2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic Acid Phenylamide4-Fluoro-α-(2-methyl-1-oxopropyl)-γ-oxo-N,β-diphenyl-benzenebutanamide
数据登录号
CAS号
描述信息
An Atorvastatin intermediate. Atorvastatin is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
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参考文献
• Winters, R., et al.: J. Med. Chem., 36, 1735 (1993)
• Hagmann, W., et al.: Bioorg. Med. Chem. Lett., 10, 1975 (1993)
• Istvan, E., et al.: Science, 292, 1160 (2001)