物质信息
ID:385088
名称和标识
IUPAC传统名
brolin
IUPAC标准名
(Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropimidamide
别名
N-[(1S)-1-(Aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]benzamideF-Amidine
数据登录号
CAS号
描述信息
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for
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参考文献
• Hill, J.A. et al.: J. Immunol., 171, 538 (2009)
• Jones, J.E. et al.: Curr. Opin. Drug Discov. Dev., 12, 616 (2009)
• Luo, Y. et al.: Biochemistry, 45, 11727 (2009)
• Knuckley, B. et al.: Biochemistry, 49, 1 (2009)
• Slack, J.L. et al.: Cell. Mol. Life Sci.,