物质信息
ID:384235
名称和标识
IUPAC标准名
N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
IUPAC传统名
N-{6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
别名
LDE 225NVP-LDE 225Erismodegibrel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-1,1'-biphenyl]-3-carboxamide
数据登录号
CAS号
描述信息
A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic.
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参考文献
• Berman, D., et al.: Science, 297, 1559 (2002)
• Varjosalo, M., et al.: Cell, 133, 537 (2002)
• Theunissen, J., et al.: Cancer Res., 69, 6007 (2002)