物质信息
ID:384216
名称和标识
IUPAC传统名
prinaberel
IUPAC标准名
7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol
别名
ERB 0412-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol2-(3-Fluoro-4-hydroxyphenyl)-7-vinylbenzoxazol-5-olPrinaberel7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
数据登录号
CAS号
描述信息
ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).
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参考文献
• Malamas, et al.: J. Med. Chem., 47, 5021 (2003)
• Cvoro, et al.: J. Immunol., 180, 630 (2003)
• Harris, et al.: Endocrinology, 144. 4241 (2003)