物质信息
ID:383959
名称和标识
IUPAC标准名
2-(4-{[(3,5-dimethylphenyl)carbamoyl]methyl}phenoxy)-2-methylpropanoic acid
IUPAC传统名
efaproxiral
别名
Efaproxiral2-[4-[2-[(3,5-Dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic AcidRSR 13
数据登录号
CAS号
化合物性质
理化性质
外观
Off-White to Tan Solid
溶解度
Methanol
DMSO
熔点
48-50°C
安全信息
MSDS下载
保存条件
Refrigerator
产品相关信息
质检报告
描述信息
Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).
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参考文献
• Abraham, D.J., et al.: Biochemistry, 31, 9141 (1992)
• Pagel, P.S., et al.: J. Pharmacol. Exp. Ther., 285, 1 (1992)
• Kleinberg, L., et al.: J. Clin. Oncol., 17, 2593 (1992)