物质信息
ID:380699
名称和标识
IUPAC传统名
cyclophosphamide hydrate
别名
Cyclophosphamide monohydrateCytoxanHexadrinNSC 26271CyclostinMitoxanCycloblastinEndoxanGenoxalN,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide Monohydrate
IUPAC标准名
2-[bis(2-chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one hydrate
数据登录号
CAS号
化合物性质
理化性质
溶解度
Benzene
Chloroform
Dioxane
Ethylene Glycol
Alcohol
外观
White to Off-White Solid
熔点
41-45°C
产品相关信息
质检报告
安全信息
保存条件
Refrigerator
MSDS下载
描述信息
It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This sub
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参考文献
• Fraiser, L.H., et al.: Drugs, 42, 781 (1962)
• Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962)
• Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1962)