物质信息
ID:377161
名称和标识
IUPAC传统名
brefeldin A
IUPAC标准名
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
别名
Brefeldin ANSC 244390NSC 89671NectrolideNSC 56310Synergisidinγ-4-Dihdyroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid, λ-Lactone, BFA, Cyanein, Ascotoxin, Decumbin
数据登录号
CAS号
描述信息
A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.
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参考文献
• Mordente, J.A., et al.: J. Urol., 159, 275 (1986)
• Misumi, Y., et al.: J. Biol. Chem., 261 (1986)
• Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1986)
• Nojiri, H., et al.: FEBS Letters, 453, 140 (1986)