物质信息
ID:377149
名称和标识
IUPAC标准名
[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid
别名
VelcadeBortezomibPS 341NSC 681239MLN 341PS 314DPBAMG 341RadiciolLDP 341B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid
IUPAC传统名
bortezomib
数据登录号
CAS号
化合物性质
理化性质
熔点
122-124°C
溶解度
Dimethyl Sulfoxide
Methanol
Ethanol
Chloroform
外观
White to Off-White Solid
安全信息
MSDS下载
保存条件
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
产品相关信息
质检报告
描述信息
Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.
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参考文献
• Drahl C.: Chem. and Eng. News, 87, 41 (2009)
• Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005)