物质信息
ID:375284
名称和标识
IUPAC标准名
4,7,11-trioxa-16-azatetracyclo[8.7.0.03,8.012,16]heptadeca-1,3(8),9-trien-17-one
IUPAC传统名
4,7,11-trioxa-16-azatetracyclo[8.7.0.03,8.012,16]heptadeca-1,3(8),9-trien-17-one
别名
2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-oneLiD 37BDP 37CX 614
数据登录号
CAS号
化合物性质
理化性质
溶解度
DMSO
Methanol
Chloroform
熔点
149-151°C
外观
White to Off-White Solid
产品相关信息
质检报告
安全信息
MSDS下载
保存条件
Refrigerator
描述信息
It is one of a series of AMPA modulators for the potential treatment of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI). An ampakine drug that facilitates activation of glutamatergic AMPA receptors.
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参考文献
• Marini, A., et al.: J. Biol. Chem., 273, 29394 (1996)
• Balkowiec, A., et al.: J. Neurosci., 22, 10399 (1996)
• Arai, A., et al.: J. Pharmacol. Exp. Ther., 278, 627 (1996)
• Dicou, E., et al.: Brain Res., 970, 221 (1996)