物质信息
ID:374784
名称和标识
别名
EmendAprepitant5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-oneMK 0869ONO 7436MK 869L 754030
IUPAC标准名
3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
IUPAC传统名
aprepitant
数据登录号
CAS号
化合物性质
理化性质
熔点
244-246°C
外观
White to Off-White Solid
溶解度
Chloroform
Methanol
产品相关信息
质检报告
安全信息
MSDS下载
保存条件
-20°C Freezer
描述信息
A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E
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参考文献
• Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998)
• Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (1998)
• Campos, D., et al.: J. Clin. Oncol., 19, 1759 (1998)
• Van Belle, S., et al.: Cancer, 94, 3032 (1998)