物质信息
ID:374701
名称和标识
IUPAC传统名
6-(phenylamino)quinoline-5,8-dione
IUPAC标准名
6-(phenylamino)-5,8-dihydroquinoline-5,8-dione
别名
6-ANILINO-5,8-QUINOLINEDIONE6-(Phenylamino)-5,8-quinolinedione6-Anilinoquinoline-5,8-quinone5,8-Dihydro-5,8-dioxo-6-(phenylamino)quinolineLY 83583
数据登录号
CAS号
描述信息
Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.
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参考文献
• Mulsch, A. J.: J. Pharmacol. Exp. Ther., 247, 283 (1987)
• Macleod, K.M., et al.: Mol. Pharmacol., 32, 59 (1987)
• Beasley, D., et al
• Mulsch, A., et al.: Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 119 (1987)
• Light, D.B., et al.: Science, 243, 383 (1987)