物质信息
ID:373111
名称和标识
别名
ValdoxanAgomelatineS 20098N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamideN-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide
IUPAC标准名
N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
IUPAC传统名
agomelatine
数据登录号
CAS号
描述信息
Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human
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参考文献
• Yous, S., et al.: J. Med. Chem., 35, 1484 (1992)
• Cajochen, C., et al.: J. Pineal Res., 35, 149 (1992)
• Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (1992)