物质信息
ID:372163
名称和标识
IUPAC标准名
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-7-carboxamide
IUPAC传统名
2-[(2R)-2-methylpyrrolidin-2-yl]-3H-1,3-benzodiazole-4-carboxamide
别名
A 8616952-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamideABT 888
数据登录号
CAS号
描述信息
ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
分子图谱
暂无数据
点击上传数据
参考文献
• Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2002)
• Tentori, L., et al.: Pharmacol. Res., 52, 25 (2002)
• Kim, M., et al.: Cell, 119, 803 (2002)
• Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002)