Drug Groups

approved

Description

Brimonidine is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis. [Wikipedia]

Indication

For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Pharmacology

Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow.

Toxicity

Oral LD₅₀ is 50 mg/kg in mice and 100 mg/kg in rats.

Affected Organisms

Biotransformation

Metabolized primarily by the liver.

Absorption

Minimal systemic absorption occurs after ocular insertion.

Half Life

2 hours

Elimination

It is metabolized primarily by the liver. Urinary excretion is the major route of elimination of the drug and its metabolites.

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