General description This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34. Other Notes Values of analytes vary lot to lot. Biochem/physiol Actions Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.