物质信息
ID:3569
名称和标识
IUPAC传统名
eucalyptol
别名
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane1,8-Cineole1,8-epoxy-p-menthaneEucalyptol [usan]Eukalyptol [czech]Soledump-Menthane, 1,8-epoxy-2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane4,7,7-trimethyl-8-oxabicyclo[2.2.2]octaneCasella-med brand of cineoleEucalyptol (natural)Eucalyptol (usan)Terpan{1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane}Eucalyptollimonene oxidecajeputolcineol1,8-cineol (eucalyptol)2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl-CucalyptolEucalyptus oilFEMA No. 2465UNII-RV6J6604TKZedoary oilZineolp-Menthane, 1,8-epoxy- (VAN){2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane}eucalyptole1,8-oxido-p-menthanecineole1,3,3-Trimethyl-2-oxabicyclo[2,2,2]octan1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane (ACD/Name 4.0)BIDD:ER0481CNLEukalyptolP-cineoleWLN: T66 A B AOTJ B1 B1 F1{2-Oxabicyclo[2.2.2]octane,} 1,3,3-trimethyl-1,8-cineol1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octaneCineolumEucapur
IUPAC标准名
1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane
数据登录号
CAS号
化合物性质
理化性质
疏水性(logP)
2.74 [GRIFFIN,S ET AL. (1999)]
溶解度
3.5 mg/mL at 21 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
描述信息
Drug Groups
nutraceutical
Description
Eucalyptol is a natural organic compound which is a colorless liquid. It is a cyclic ether and a monoterpenoid. Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant. It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effective treatment for nonpurulent rhinosinusitis. Eucalyptol reduces inflammation and pain when applied topically. It kills leukaemia cells in vitro.
Toxicity
Oral, rat LD50: 2480 mg/kg
Affected Organisms
Humans and other mammals
References
•
Bastos VP, Gomes AS, Lima FJ, Brito TS, Soares PM, Pinho JP, Silva CS, Santos AA, Souza MH, Magalhaes PJ: Inhaled 1,8-Cineole Reduces Inflammatory Parameters in Airways of Ovalbumin-Challenged Guinea Pigs. Basic Clin Pharmacol Toxicol. 2010 Aug 16.
[Pubmed]
External Links
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参考文献
• Bastos VP, Gomes AS, Lima FJ, Brito TS, Soares PM, Pinho JP, Silva CS, Santos AA, Souza MH, Magalhaes PJ: Inhaled 1,8-Cineole Reduces Inflammatory Parameters in Airways of Ovalbumin-Challenged Guinea Pigs. Basic Clin Pharmacol Toxicol. 2010 Aug 16. Pubmed