物质信息
ID:355902
名称和标识
IUPAC传统名
docetaxel
IUPAC标准名
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
别名
Taxotere®Docetaxel
化合物性质
产品相关信息
Empirical Formula (Hill Notation)
C43H53NO14
级别
purum
纯度
≥97.0% (HPLC)
杂质
~6% water
安全信息
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
MSDS下载
德国WGK号
3
RTECS编号
DA4172750
理化性质
熔点
186-192 °C (dec.)
溶解度
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描述信息
Frequently Asked Questions
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Application
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Docetaxel can be used to study antibiotics, cell biology, cell signaling, neuroscience and apoptosis and the cell cycle. Docetaxel has been used to study the prevention of chemotherapy-induced alopecia, as well as the treatment of non-small-cell lung cancer in patients contraindicated for standard chemotherapy. Docetaxel has also been used to study the role of hypoxia-inducible factor-1α and -2α in androgen insensitive prostate cancer cells.
Biochem/physiol Actions
Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β-tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.
法律信息
Taxotere 注册商标 Sanofi-Aventis
Live Chat and Frequently Asked Questions are available for this Product.
Application
Do you have application information on this product that you would like to share?
Docetaxel can be used to study antibiotics, cell biology, cell signaling, neuroscience and apoptosis and the cell cycle. Docetaxel has been used to study the prevention of chemotherapy-induced alopecia, as well as the treatment of non-small-cell lung cancer in patients contraindicated for standard chemotherapy. Docetaxel has also been used to study the role of hypoxia-inducible factor-1α and -2α in androgen insensitive prostate cancer cells.
Biochem/physiol Actions
Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β-tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.
法律信息
Taxotere 注册商标 Sanofi-Aventis
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