物质信息
ID:354810
名称和标识
IUPAC标准名
(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
IUPAC传统名
deoxyglucose
别名
2-脱氧-D-葡糖D-2-脱氧葡萄糖2-Deoxy-D-glucose2-Deoxy-D-arabinohexose
化合物性质
理化性质
熔点
146-147 °C(lit.)
148-153 °C
比旋光度
[α]20/D +46.5±2°, 45 hr, c = 0.5% in H2O
溶解度
H2O: soluble50 mg/mL, clear, colorless to faintly yellow
安全信息
产品相关信息
Empirical Formula (Hill Notation)
C6H12O5
纯度
≥98.0% (HPLC)
描述信息
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
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