物质信息
ID:351775
名称和标识
IUPAC标准名
6-bromo-5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
别名
4-Bromo-calcium Ionophore A231874-Bromo-A231874-Bromo-calcimycin
IUPAC传统名
6-bromo-5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
化合物性质
产品相关信息
Empirical Formula (Hill Notation)
C29H36BrN3O6
纯度
≥95.0% (N)
安全信息
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明
P261-P280-P305+P351+P338
德国WGK号
3
GHS警示词
Warning
危险公开号
20/21/22-36/37/38
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
安全公开号
26-36/37
保存温度
2-8°C
欧盟危险性物质标志
有害性 (Xn)GHS危险声明
H302-H312-H315-H319-H332-H335
MSDS下载
理化性质
溶解度
ethanol: soluble20 mg/mL, clear, yellow
描述信息
Application
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Bromo-A23187, a nonfluorescent ionophore, has been used in photolysis of a caged-Ca2+ compound and in [Ca2+]i elevation protocols1. It can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Other Notes
In biological environment, bromo-A23187 has a higher selectivity for Ca2+ over Mg2+ than A231872
Biochem/physiol Actions
Ionophores disrupt transmembrane ion concentration gradients which are required for proper functioning and survival of microorganisms. An ionophore, such as Bromo-A23187, increases the permeability of biological membranes to calcium.
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Bromo-A23187, a nonfluorescent ionophore, has been used in photolysis of a caged-Ca2+ compound and in [Ca2+]i elevation protocols1. It can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Other Notes
In biological environment, bromo-A23187 has a higher selectivity for Ca2+ over Mg2+ than A231872
Biochem/physiol Actions
Ionophores disrupt transmembrane ion concentration gradients which are required for proper functioning and survival of microorganisms. An ionophore, such as Bromo-A23187, increases the permeability of biological membranes to calcium.
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