物质信息
ID:350515
名称和标识
IUPAC传统名
colchicine
别名
秋水仙素Colchicine
IUPAC标准名
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.02,7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide
化合物性质
安全信息
欧盟危险性物质标志
剧毒 (T+)RTECS编号
GH0700000
联合国危险货物编号
1544
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
急性毒性（口服，皮肤接触，吸入），类别1,2,3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
GHS警示词
Danger
RID/ADR
UN 1544 6.1/PG 1
安全公开号
53-45
GHS危险声明
H300+H330-H318-H340
联合国危险货物包装类别(PG)
1
GHS警示性声明
P201-P260-P264-P280-P284-P301+P310
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
联合国危险货物等级
6.1
危险公开号
46-28
德国WGK号
3
MSDS下载
理化性质
外观
white to yellow powder
溶解度
ethanol: soluble50 mg/mL
熔点
150-160 °C (dec.)(lit.)
产品相关信息
纯度
≥95% (HPLC)
Empirical Formula (Hill Notation)
C22H25NO6
药理学性质
相关基因信息
human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
描述信息
包装
1, 5 g in poly bottle
100, 500 mg in poly bottle
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
1, 5 g in poly bottle
100, 500 mg in poly bottle
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
分子图谱
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参考文献
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