物质信息
ID:350298
名称和标识
IUPAC标准名
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
IUPAC传统名
leflunomide
别名
5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilideLeflunomide
化合物性质
安全信息
安全公开号
26
RID/ADR
UN 2811 6.1/PG 3
RTECS编号
NY2354200
MSDS下载
GHS危险声明
H301-H315-H319-H335
德国WGK号
3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
欧盟危险性物质标志
有害性 (Xn)GHS警示词
Danger
联合国危险货物等级
6.1
联合国危险货物编号
2811
保存温度
2-8°C
GHS警示性声明
P261-P301+P310-P305+P351+P338
危险公开号
22-36/37/38
联合国危险货物包装类别(PG)
3
产品相关信息
Empirical Formula (Hill Notation)
C12H9F3N2O2
药理学性质
相关基因信息
human ... DHODH(1723)
描述信息
Biochem/physiol Actions
Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
Application
By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation1 and treatment of rheumatoid arthritis2 and other autoimmune diseases.
Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
Application
By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation1 and treatment of rheumatoid arthritis2 and other autoimmune diseases.
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