物质信息
ID:350085
名称和标识
IUPAC标准名
(2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-4-methyl-N-[(2S)-1-oxohexan-2-yl]pentanamide
别名
Calpain Inhibitor IALLNN-Acetyl-Leu-Leu-Norleu-alN-Acetyl-L-leucyl-L-leucyl-L-norleucinalAc-LLnL-CHOMG-101
IUPAC传统名
(2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-4-methyl-N-[(2S)-1-oxohexan-2-yl]pentanamide
化合物性质
药理学性质
相关基因信息
human ... CAPN1(823), CTSB(1508), PSMA1(5682)
安全信息
德国WGK号
3
MSDS下载
保存温度
-20°C
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
理化性质
溶解度
ethanol: soluble
DMSO: soluble
外观
white powder
产品相关信息
Empirical Formula (Hill Notation)
C20H37N3O4
纯度
≥97% (TLC)
描述信息
Application
Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Biochem/physiol Actions
Can initiate apoptosis in HL-60 cells1 but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.2 Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.3 Blocks induction of nitric oxide synthase by LPS in macrophages.4
Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Biochem/physiol Actions
Can initiate apoptosis in HL-60 cells1 but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.2 Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.3 Blocks induction of nitric oxide synthase by LPS in macrophages.4
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参考文献
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