物质信息
ID:350011
名称和标识
IUPAC标准名
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate
IUPAC传统名
forskolin
别名
Coleonol7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-oneForskolinColforsin
化合物性质
安全信息
欧盟危险性物质标志
有害性 (Xn)GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS警示词
Warning
GHS危险声明
H312
GHS警示性声明
P280
安全公开号
22-36/37
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
RTECS编号
QL6150000
MSDS下载
德国WGK号
3
危险公开号
21
产品相关信息
生物来源
from Coleus forskohlii
Empirical Formula (Hill Notation)
C22H34O7
纯度
≥98% (HPLC)
药理学性质
相关基因信息
human ... OPRK1(4986), SLC2A10(81031), TNF(7124)
理化性质
溶解度
DMSO: soluble5 mg/mL (stable at least 6 months at room temperature)
ethanol: soluble
外观
off-white powder
描述信息
Biochem/physiol Actions
Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
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