物质信息
ID:349626
名称和标识
IUPAC标准名
2-ethoxy-4-({[(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl]carbamoyl}methyl)benzoic acid
IUPAC传统名
repaglinide
别名
PrandinNovoNorm(S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acidRepaglinide
化合物性质
安全信息
MSDS下载
德国WGK号
2
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号
DI0876305
保存温度
2-8°C
理化性质
外观
white solid
溶解度
DMSO: >20 mg/mL
熔点
129-130.2 °C
产品相关信息
Empirical Formula (Hill Notation)
C27H36N2O4
纯度
≥98% (HPLC)
药理学性质
相关基因信息
human ... KCNJ1(3758)
描述信息
Biochem/physiol Actions
Repaglinide is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. It represents a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which were developed for the treatment of type 2 diabetes.
Repaglinide is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. It represents a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which were developed for the treatment of type 2 diabetes.
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