物质信息
ID:349046
名称和标识
IUPAC传统名
lamivudine
IUPAC标准名
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
别名
3TCHeptovirEpivirEpivir-HBVZeffixLamivudine2′,3′-Dideoxy-3′-thiacytidine
化合物性质
安全信息
GHS警示词
Warning
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS危险声明
H315-H319-H335
欧盟危险性物质标志
刺激性 (Xi)GHS警示性声明
P261-P305+P351+P338
MSDS下载
保存温度
room temp
危险公开号
36/37/38
安全公开号
26-36
德国WGK号
3
理化性质
溶解度
DMSO: >20 mg/mL
外观
white to off-white powder
产品相关信息
纯度
≥98% (HPLC)
Empirical Formula (Hill Notation)
C8H11N3O3S
描述信息
Biochem/physiol Actions
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.
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