物质信息
ID:348918
名称和标识
IUPAC标准名
7-nitro-1H-indole-2-carboxylic acid
IUPAC传统名
7-nitro-1H-indole-2-carboxylic acid
别名
NSC 698777-Nitro-1H-indole-2-carboxylic acid7-Nitroindole-2carboxylic acidCRT0044876
化合物性质
安全信息
GHS危险品标识
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
危险公开号
36-43
安全公开号
26-36/37
GHS警示词
Danger
GHS警示性声明
P261-P305+P351+P338-P342+P311
保存温度
room temp
欧盟危险性物质标志
刺激性 (Xi)MSDS下载
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
德国WGK号
3
GHS危险声明
H319-H334
产品相关信息
Empirical Formula (Hill Notation)
C9H6N2O4
纯度
≥98% (HPLC)
理化性质
外观
powder
溶解度
DMSO: >20 mg/mL
描述信息
Biochem/physiol Actions
CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities-essential steps in excision repair-with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.
CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities-essential steps in excision repair-with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.
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