物质信息
ID:348310
名称和标识
IUPAC标准名
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
IUPAC传统名
fluconazole
别名
Fluconazole2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
化合物性质
产品相关信息
Empirical Formula (Hill Notation)
C13H12F2N6O
纯度
≥98% (HPLC)
安全信息
GHS危险声明
H302-H315-H319-H335
欧盟危险性物质标志
有害性 (Xn)RTECS编号
XZ4810000
德国WGK号
3
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
危险公开号
22-36/37/38
GHS警示词
Warning
MSDS下载
GHS警示性声明
P261-P305+P351+P338
安全公开号
26-36
保存温度
room temp
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
药理学性质
相关基因信息
human ... CYP1A2(1544)
理化性质
溶解度
DMSO: soluble5 mg/mL
外观
powder
描述信息
Biochem/physiol Actions
Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8929.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. F8929.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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