物质信息
ID:348134
名称和标识
IUPAC标准名
1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
IUPAC传统名
fenobam
别名
FenobamN-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea
化合物性质
安全信息
欧盟危险性物质标志
有毒 (T)GHS危险声明
H300
危险公开号
25
联合国危险货物包装类别(PG)
3
德国WGK号
3
MSDS下载
个人保护装置
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS警示性声明
P264-P301+P310
联合国危险货物等级
6.1
联合国危险货物编号
2811
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
保存温度
2-8°C
GHS警示词
Danger
RID/ADR
UN 2811 6.1/PG 3
安全公开号
45
产品相关信息
纯度
≥98% (HPLC)
Empirical Formula (Hill Notation)
C11H11ClN4O2
理化性质
溶解度
DMSO: >20 mg/mL
外观
white solid
描述信息
Biochem/physiol Actions
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
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