物质信息
ID:346890
名称和标识
别名
对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物甲氨蝶呤氟安定 水合物L-氨甲喋呤 水合物氨甲喋呤 水合物甲氨蝶呤 水合物MethotrexateMTX 水合物氨甲叶酸 水合物L-Amethopterin hydrateMTX hydrateMethotrexate hydrate4-Amino-10-methylfolic acid hydrateL-4-Amino-N10-methylpteroylglutamic acid hydrateAntifolan hydrateMethylaminopterin hydrate
IUPAC传统名
hydrate methotrexate
IUPAC标准名
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
化合物性质
安全信息
GHS警示词
Danger
联合国危险货物包装类别(PG)
3
德国WGK号
3
危险公开号
61-25-36/38
RID/ADR
UN 1544 6.1/PG 3
欧盟危险性物质标志
有毒 (T)GHS警示性声明
P201-P301+P310-P305+P351+P338-P308+P313
安全公开号
53-26-36/37-45
联合国危险货物编号
1544
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
GHS危险声明
H301-H315-H319-H360
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
MSDS下载
保存温度
-20°C
联合国危险货物等级
6.1
RTECS编号
MA1225000
产品相关信息
Empirical Formula (Hill Notation)
C20H22N8O5 · xH2O
适用性
meets EP, USP testing specifications
描述信息
Application
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
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