Drug Groups

approved

Description

A cephalosporin antibiotic. [PubChem]

Indication

Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.

Pharmacology

Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.

Toxicity

Rat intravenous LD₅₀ is 4000 mg/kg.

Affected Organisms

Biotransformation

Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.

Half Life

30 minutes

Protein Binding

65-80%

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