物质信息
ID:310609
名称和标识
IUPAC传统名
flurbiprofen
IUPAC标准名
2-(3-fluoro-4-phenylphenyl)propanoic acid
别名
Flurbiprofen氟比洛芬(±)-2-Fluoro-α-methyl-4-biphenylacetic acid(±)-2-氟-α-甲基-4-联苯基乙酸L-790,330
化合物性质
安全信息
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
GHS警示词
Danger
欧盟危险性物质标志
有毒 (T)RID/ADR
UN 2811 6.1/PG 3
MSDS下载
GHS警示性声明
P301+P310
RTECS编号
DU8341000
安全公开号
36/37/39-45
联合国危险货物包装类别(PG)
3
个人保护装置
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
联合国危险货物等级
6.1
德国WGK号
3
GHS危险声明
H301
联合国危险货物编号
2811
危险公开号
25
产品相关信息
线性分子式
C6H5C6H3(F)CH(CH3)CO2H
纯度
97%
理化性质
熔点
110-112 °C(lit.)
描述信息
Biochem/physiol Actions
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
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