物质信息
ID:310451
名称和标识
别名
1-甲基-3-异丁基黄嘌呤3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮3-异丁基-1-甲基黄嘌呤3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮3-Isobutyl-1-methylxanthineIBMX1-Methyl-3-isobutylxanthine3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
IUPAC传统名
3 isobutyl 1 methylxanthine
IUPAC标准名
1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
化合物性质
理化性质
熔点
200-201 °C(lit.)
安全信息
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
欧盟危险性物质标志
有害性 (Xn)MSDS下载
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
德国WGK号
3
危险公开号
22
GHS警示词
Warning
RTECS编号
ZD8500000
GHS危险声明
H302
产品相关信息
纯度
99%
Empirical Formula (Hill Notation)
C10H14N4O2
描述信息
Application
环核苷酸磷酸二酯酶蛋白抑制剂2,3
包装
1 g in glass bottle
100 mg in glass bottle
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1
环核苷酸磷酸二酯酶蛋白抑制剂2,3
包装
1 g in glass bottle
100 mg in glass bottle
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1
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