物质信息
ID:2809
名称和标识
别名
pyrimidin-2-one beta-ribofuranosidePyrimidin-2-one ribonucleosidePyrimidin-2-one beta-D-ribofuranoside1-beta-D-ribofuranosylpyrimidin-2(1H)-oneDHZ1-beta-D-ribofuranosyl-2(1H)-pyrimidinoneZebularine
IUPAC传统名
zebularine
IUPAC标准名
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
化合物性质
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描述信息
Drug Groups
experimental
Description
A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
分子图谱
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参考文献
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