Drug Groups

approved; nutraceutical

Description

The N-acetyl derivative of glucosamine. [PubChem]

Indication

For the treatment and prevention of osteoarthritis, by itself or in combination with chondroitin sulfate.

Toxicity

Mouse, intravenous LD₅₀ is 4170 mg/kg. Side effects that have been reported are mainly mild gastrointestinal complaints such as heartburn, epigastric distress and diarrhea. No allergic reactions have been reported including sulfa-allergic reactions to glucosamine sulfate.

Affected Organisms

Biotransformation

A significant fraction of ingested glucosamine is catabolized by first-pass metabolism in the liver.

Absorption

Approximately 90% of orally administered glucosamine (salt form) gets absorbed from the small intestine.

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