物质信息
ID:1864826
名称和标识
IUPAC传统名
crenolanib
IUPAC标准名
1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-amine
别名
crenolanib1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-amine1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamineARO 002ARO-002CP 868596CP-868,596CP-868596CP868569
国际非专利药品(INN)
crenolanibcrenolanibum
数据登录号
PubChem CID
CAS号
PubMed文献链接
CHEMBL
SureChEMBL数据库
PDBeChem数据库
维基百科标题
DrugBank ID
BindingDB数据库
KEGG DRUG Database
CHEBI ID
PubChem SID
化合物性质
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描述信息
A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia.
分子图谱
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参考文献
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