物质信息
ID:184774
名称和标识
别名
对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物氟安定 水合物L-氨甲喋呤 水合物氨甲喋呤 水合物MTX 水合物氨甲叶酸 水合物甲氨蝶呤 水合物Methotrexate hydrate
IUPAC传统名
hydrate methotrexate
IUPAC标准名
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
化合物性质
安全信息
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
安全公开号
53-26-36/37-45
联合国危险货物等级
6.1
欧盟危险性物质标志
有毒 (T)德国WGK号
3
保存温度
-20°C
联合国危险货物包装类别(PG)
3
联合国危险货物编号
1544
GHS警示词
Danger
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS危险声明
H301-H315-H319-H360
GHS警示性声明
P201-P301+P310-P305+P351+P338-P308+P313
RID/ADR
UN 1544 6.1/PG 3
危险公开号
61-25-36/38
理化性质
溶解度
H2O: insoluble
外观
powder
产品相关信息
适用性
suitable for insect cell culture
suitable for cell culture
纯度
≥98% (HPLC)
描述信息
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Recommended for use in cell culture and molecular biology applications at 0.01-300 μM in nucleoside-free cell culture medium to select for DHFR expression.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Biochem/physiol Actions
Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.
Live Chat and Frequently Asked Questions are available for this Product.
Application
Recommended for use in cell culture and molecular biology applications at 0.01-300 μM in nucleoside-free cell culture medium to select for DHFR expression.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Biochem/physiol Actions
Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.
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