物质信息
ID:184570
名称和标识
IUPAC传统名
2-methoxyestradiol
别名
1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether2-Hydroxyestradiol 2-methyl ether2-Methoxyestradiol
IUPAC标准名
(1S,10R,11S,14S,15S)-4-methoxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-triene-5,14-diol
化合物性质
安全信息
GHS警示性声明
P201-P261-P280-P301+P310-P305+P351+P338-P311
RTECS编号
KG7537500
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
联合国危险货物编号
3077
GHS危险品标识
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
急性毒性（口服，皮肤接触，吸入），类别1,2,3
GHS危险声明
H301-H311-H315-H319-H331-H335-H350-H360-H372
RID/ADR
UN 3077 9/PG 3
联合国危险货物等级
9
德国WGK号
3
GHS警示词
Danger
欧盟危险性物质标志
有毒 (T)联合国危险货物包装类别(PG)
3
安全公开号
53-22-26-36/37/39-45
危险公开号
45-46-60-61-23/24/25-36/37/38-48
理化性质
溶解度
ethanol: soluble10 mg/mL
DMSO: soluble10 mg/mL
H2O: insoluble
外观
white to faint yellow powder
药理学性质
相关基因信息
human ... ESR1(2099), ESR2(2100)
描述信息
Biochem/physiol Actions
2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis. A major estradiol metabolite, it has little affinity for classical estrogen receptors.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6383.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis. A major estradiol metabolite, it has little affinity for classical estrogen receptors.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6383.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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