Application
Sulfanitran is used to stimulate MRP2. It is used to stimulate the MRP2-mediated transport of lipophilic amphipathic drugs1. It is used to study the efflux of chemotherapeutics in tumor cell lines1.
Biochem/physiol Actions
Sulfanitran stimulates the ATP binding cassette family transporter multidrug resistance protein 2 (MRP2). Sulfanitran increases the affinity of MRP2 for estradiol-17-β-D-glucuronide2. It stimulates the vectorial transport of saquinavir, a MRP2 substrate, across polarized MDCKII monolayers2.