物质信息
ID:184437
名称和标识
IUPAC标准名
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
IUPAC传统名
fludarabine
别名
F-ara-AFludarabine des-phosphate2-Fluoroadenine-9-β-D-arabinofuranoside9-β-D-Arabinofuranosyl-2-fluoroadenine
化合物性质
安全信息
GHS危险声明
H302
危险公开号
22
RTECS编号
AU6207000
欧盟危险性物质标志
有害性 (Xn)德国WGK号
3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS警示词
Warning
保存温度
2-8°C
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
药理学性质
相关基因信息
human ... ADORA3(140)rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
描述信息
Warning
The name fludarabine refers to 9-β-D-arabinofuranosyl-2-fluoroadenine 5′-phosphate, but is sometimes erroneously used for this compound, which lacks the phosphate.
Biochem/physiol Actions
Fludarabine (the 5′-phosphate) is a prodrug that is converted to F-ara-A, which enters cells and accumulates primarily as the 5′-triphosphate. F-ara-A interferes with DNA synthesis and repair and induces apoptosis of cancer cells. F-ara-A also strongly inhibits DNA methylation, particularly methylation of cytosine in CpG dinucleotide sequences.1
The name fludarabine refers to 9-β-D-arabinofuranosyl-2-fluoroadenine 5′-phosphate, but is sometimes erroneously used for this compound, which lacks the phosphate.
Biochem/physiol Actions
Fludarabine (the 5′-phosphate) is a prodrug that is converted to F-ara-A, which enters cells and accumulates primarily as the 5′-triphosphate. F-ara-A interferes with DNA synthesis and repair and induces apoptosis of cancer cells. F-ara-A also strongly inhibits DNA methylation, particularly methylation of cytosine in CpG dinucleotide sequences.1
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