物质信息
ID:184365
名称和标识
别名
CompactinML-236BMevastatin
IUPAC标准名
(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
IUPAC传统名
mevastatin
化合物性质
安全信息
保存温度
2-8°C
德国WGK号
3
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
理化性质
溶解度
DMSO: soluble20 mg/mL
ethanol: soluble25 mg/mL
外观
white powder
产品相关信息
纯度
≥95% (HPLC)
药理学性质
相关基因信息
human ... HMGCL(3155), HMGCR(3156)rat ... Hmgcr(25675)
描述信息
Biochem/physiol Actions
HMG-CoA reductase inhibitor. Cholesterol lowering drug. Inhibits myoblast formation. An antibiotic shown to cause apoptosis, apparently by inhibiting post-translational prenylation of proteins such as Ras. Similarly, mevastatin increases eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho.
HMG-CoA reductase inhibitor. Cholesterol lowering drug. Inhibits myoblast formation. An antibiotic shown to cause apoptosis, apparently by inhibiting post-translational prenylation of proteins such as Ras. Similarly, mevastatin increases eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho.
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