物质信息
ID:184351
名称和标识
别名
[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl esterMethyl N-(5-thenoyl-2-benzimidazolyl)carbamateR 17934OncodazoleMethyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamateNocodazole
IUPAC标准名
methyl N-[5-(thiophene-2-carbonyl)-1H-1,3-benzodiazol-2-yl]carbamate
IUPAC传统名
nocodazol
化合物性质
安全信息
欧盟危险性物质标志
有害性 (Xn)GHS危险品标识
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
安全公开号
36/37
德国WGK号
3
RTECS编号
DD6521000
GHS危险声明
H341-H361d
GHS警示性声明
P281
GHS警示词
Warning
危险公开号
63-68
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度
2-8°C
理化性质
溶解度
DMSO: soluble10 mg/mL (may require heating)
H2O: insoluble
外观
white powder
熔点
300 °C (dec.)
产品相关信息
纯度
≥99% (TLC)
产品质量级别
PREMIUM
药理学性质
相关基因信息
human ... TUBB(203068)
描述信息
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to β?tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Arrests the cell cycle at G2/M phase. Prevents phosphorylation of the T cell antigen receptor and inhibits its activity. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway and induces apoptosis in several normal and tumor cell lines.
Antimitotic agent that disrupts microtubules by binding to β?tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Arrests the cell cycle at G2/M phase. Prevents phosphorylation of the T cell antigen receptor and inhibits its activity. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway and induces apoptosis in several normal and tumor cell lines.
分子图谱
暂无数据
点击上传数据
参考文献
暂无数据
点击上传数据