物质信息
ID:1841680
名称和标识
别名
ximelagatranExantaExartaH 376-95H 376/95H 37695ethyl 2-[[(1R)-1-cyclohexyl-2- [(2S)-2-[[4-(N'-hydroxycarbamimidoyl) phenyl]methylcarbamoyl]azetidin-1-yl]- 2-oxo-ethyl]amino]acetateximelagatran (oxime form)
国际非专利药品(INN)
ximelagatranximelagatranum
IUPAC标准名
ethyl 2-{[(1R)-1-cyclohexyl-2-[(2S)-2-({[4-(N'-hydroxycarbamimidoyl)phenyl]methyl}carbamoyl)azetidin-1-yl]-2-oxoethyl]amino}acetate
IUPAC传统名
ethyl 2-{[(1R)-1-cyclohexyl-2-[(2S)-2-({[4-(N'-hydroxycarbamimidoyl)phenyl]methyl}carbamoyl)azetidin-1-yl]-2-oxoethyl]amino}acetate
数据登录号
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CAS号
PubMed文献链接
Reaxys Registry
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CHEMBL
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SureChEMBL数据库
维基百科标题
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PubChem SID
化合物性质
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描述信息
A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted into the corresponding amidoxime. A prodrug for melagatran, ximelagatran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.
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参考文献
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