物质信息
ID:183959
名称和标识
别名
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acidMyriocin from Mycelia steriliaISP-IThermozymocidin
IUPAC标准名
(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
IUPAC传统名
myriocin
化合物性质
理化性质
外观
off-white powder
溶解度
methanol: soluble2 mg/mL
安全信息
欧盟危险性物质标志
有害性 (Xn)个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RID/ADR
UN 2811 6.1/PG 3
GHS危险声明
H301
保存温度
2-8°C
危险公开号
22
RTECS编号
JX3890000
GHS警示性声明
P301+P310
GHS警示词
Danger
联合国危险货物包装类别(PG)
3
德国WGK号
3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
联合国危险货物等级
6.1
联合国危险货物编号
2811
产品相关信息
纯度
≥98% (HPLC)
描述信息
Biochem/physiol Actions
Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.
Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.
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