物质信息
ID:183595
名称和标识
IUPAC传统名
wortmannin
IUPAC标准名
(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl acetate
别名
KY 12420Wortmannin
化合物性质
产品相关信息
纯度
≥98% (HPLC and TLC)
生物来源
from Penicillium funiculosum
产品质量级别
PREMIUM
理化性质
溶解度
DMSO: soluble
H2O: unstable
外观
off-white powder
安全信息
欧盟危险性物质标志
剧毒 (T+)安全公开号
28-36/37-45
联合国危险货物编号
3462
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
GHS危险声明
H300-H310-H330
联合国危险货物包装类别(PG)
1
GHS警示性声明
P260-P264-P280-P284-P302+P350-P310
危险公开号
26/27/28
联合国危险货物等级
6.1
GHS警示词
Danger
RID/ADR
UN 3462 6.1/PG 1
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS编号
CB9641000
保存温度
2-8°C
德国WGK号
3
药理学性质
相关基因信息
human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)
描述信息
Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
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