物质信息
ID:183522
名称和标识
别名
(S)-(-)-Propranolol hydrochloride(S)-(-)-普奈洛尔 盐酸盐(S)-1-异丙基氨基-3-(1-萘氧基)-2-丙醇 盐酸盐
IUPAC标准名
[(2S)-2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine hydrochloride
IUPAC传统名
[(2S)-2-hydroxy-3-(naphthalen-1-yloxy)propyl](isopropyl)amine hydrochloride
化合物性质
理化性质
比旋光度
[α]25/D -25.5°, c = 1.0 in ethanol(lit.)
溶解度
ethanol: soluble10 mg/mL
H2O: soluble50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
DMSO: <14.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble8.0 mg/mL
熔点
193-195 °C(lit.)
外观
powder
安全信息
欧盟危险性物质标志
有害性 (Xn)GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS警示性声明
P280
保存温度
2-8°C
GHS警示词
Warning
德国WGK号
3
GHS危险声明
H302-H312-H332
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
危险公开号
20/21/22
安全公开号
36
产品相关信息
纯度
≥98% (TLC)
药理学性质
相关基因信息
human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)
描述信息
包装
100, 500 mg in glass bottle
Biochem/physiol Actions
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites
100, 500 mg in glass bottle
Biochem/physiol Actions
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites
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