物质信息
ID:183421
名称和标识
IUPAC传统名
dexamethasone
别名
德沙美松地塞米松9α-氟-16α-甲基氢化泼尼松Dexamethasone21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮
IUPAC标准名
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
化合物性质
安全信息
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
RTECS编号
TU3980000
安全公开号
22-26-36/37-45
欧盟危险性物质标志
有害性 (Xn)危险公开号
36/37/38-42/43
保存温度
2-8°C
GHS警示性声明
P261-P280-P305+P351+P338-P342+P311
GHS警示词
Danger
德国WGK号
2
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS危险声明
H315-H317-H319-H334-H335
理化性质
外观
powder
熔点
262-264 °C(lit.)
产品相关信息
药效
4-500 ng/mL
纯度
≥97%
适用性
suitable for cell culture
药理学性质
相关基因信息
human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
描述信息
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
An anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. Use to study apoptosis, cell signaling pathways and gene expression.
Reconstitution
To prepare 20 μg/ml stock solution, add 1ml absolute ethanol per mg product; gently swirl to dissolve. Add 49 ml sterile medium per ml of ethanol added, while mixing, to acheive final concentration of 20 μg/ml.
Physical form
powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。
Live Chat and Frequently Asked Questions are available for this Product.
Application
An anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. Use to study apoptosis, cell signaling pathways and gene expression.
Reconstitution
To prepare 20 μg/ml stock solution, add 1ml absolute ethanol per mg product; gently swirl to dissolve. Add 49 ml sterile medium per ml of ethanol added, while mixing, to acheive final concentration of 20 μg/ml.
Physical form
powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。
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