物质信息
ID:182409
名称和标识
别名
PMBNPolymyxin B nonapeptide hydrochloride
IUPAC标准名
2-amino-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)-3-hydroxybutanamide
IUPAC传统名
2-amino-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)-3-hydroxybutanamide
化合物性质
安全信息
德国WGK号
3
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度
2-8°C
描述信息
Biochem/physiol Actions
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics.1,2,3 PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.4
Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics.1,2,3 PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.4
Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.
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