物质信息
ID:182262
名称和标识
IUPAC传统名
thalidomide
IUPAC标准名
2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
别名
(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione(±)-Thalidomide
化合物性质
产品相关信息
纯度
≥98%
理化性质
溶解度
DMSO: >20 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble0.6 mg/mL
ethanol: insoluble
H2O: insoluble
外观
white solid
安全信息
RTECS编号
TI4375000
GHS危险品标识
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
急性毒性（口服，皮肤接触，吸入），类别1,2,3
GHS警示性声明
P280-P301+P310
RID/ADR
UN 2811 6.1/PG 3
联合国危险货物等级
6.1
危险公开号
46-61-21-25-62
联合国危险货物编号
2811
欧盟危险性物质标志
有毒 (T)GHS警示词
Danger
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS危险声明
H301-H312-H361
联合国危险货物包装类别(PG)
3
德国WGK号
3
安全公开号
53-22-26-36/37/39-45
药理学性质
相关基因信息
human ... LITAF(9516), TNF(7124)mouse ... Nos2(18126)rat ... Nos1(24598)
描述信息
Biochem/physiol Actions
(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α); inhibitor of angiogenesis; immunosuppressive; sedative; teratogen.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T144.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α); inhibitor of angiogenesis; immunosuppressive; sedative; teratogen.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T144.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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