物质信息
ID:182231
名称和标识
IUPAC标准名
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
IUPAC传统名
trifluridine
别名
TrifluridineTrifluorothymine deoxyribosideTrifluorothymidineα,α,α-Trifluorothymidine2′-Deoxy-5-trifluoromethyluridine
化合物性质
安全信息
欧盟危险性物质标志
有害性 (Xn)危险公开号
20/21/22-40
RTECS编号
XP2087500
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
保存温度
-20°C
德国WGK号
3
GHS警示词
Warning
GHS危险声明
H302-H312-H332-H351
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
GHS警示性声明
P280
安全公开号
22-36
理化性质
熔点
190-193 °C(lit.)
产品相关信息
纯度
≥99% (HPLC)
描述信息
Application
Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s).
Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s).
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