物质信息
ID:181011
名称和标识
别名
CongocidinSinanomycinNetropsin dihydrochloride
IUPAC传统名
4-[4-(2-carbamimidamidoacetamido)-1-methylpyrrole-2-amido]-N-(2-carbamimidoylethyl)-1-methylpyrrole-3-carboxamide dihydrochloride
IUPAC标准名
4-[4-(2-carbamimidamidoacetamido)-1-methyl-1H-pyrrole-2-amido]-N-(2-carbamimidoylethyl)-1-methyl-1H-pyrrole-3-carboxamide dihydrochloride
化合物性质
理化性质
溶解度
H2O: soluble1 mg/mL
外观
faint yellow powder
安全信息
RTECS编号
DW2973000
GHS警示词
Danger
GHS警示性声明
P301+P310
危险公开号
22
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
保存温度
-20°C
RID/ADR
UN 2811 6.1/PG 3
欧盟危险性物质标志
有害性 (Xn)安全公开号
36
GHS危险声明
H301
联合国危险货物编号
2811
德国WGK号
3
联合国危险货物等级
6.1
联合国危险货物包装类别(PG)
3
产品相关信息
纯度
≥98% (HPLC and TLC)
生物来源
from Streptomyces netropsis
描述信息
Caution
Protect from light.
Biochem/physiol Actions
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
Protect from light.
Biochem/physiol Actions
Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
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